Your browser either does not support javascript, or you have javascript turned off. Www. Spandidos-publications. Com home  | about  | contact advanced search login  | register    journals international journal of molecular medicine international journal of oncology molecular medicine reports oncology reports experimental and therapeutic medicine oncology letters biomedical reports molecular and clinical oncology    general information manuscript submission subscriptions information for advertisers most read articles conferences job opportunities site map    current issue early online archive manuscript submission instructions for authors figure submission about abstracting and indexing bibliographic information contact editor and editorial academy sitemap your browser either does not support javascript, or you have javascript turned off. Antitumor effects of peroxisome proliferator activate receptor î³ ligands on anaplastic thyroid carcinoma authors: nobuyasu hayashi, shoji nakamori, nobuaki hiraoka, masanori tsujie, xu xundi, toru takano, nobuyuki amino, masato sakon, morito monden affiliations: department of surgery and clinical oncology graduate school of medicine, osaka university, suita city, osaka 565-0871, japan pages: 89-95 abstract: anaplastic thyroid carcinoma is an aggressive neoplasm and resistant to all sorts of treatment due to its rapid growth and invasive potential. Peroxisome proliferator-activated receptor î³ (pparî³) is a nuclear receptor modulating variety of biological properties, such as regulating of adipogenesis, inhibition of cancer cell proliferation or differentiation of tumor cells. The purpose of this study was to evaluate the possibility for the therapeutic effect of pparî³ ligands against anaplastic thyroid tumor in vitro. Expressions of the pparc gene and protein were examined in 5 human anaplastic carcinoma cell lines (msa, iaa, roa, k119 and koa-2). We next evaluated the effects of pparî³ ligands (thiazolidinedione, prostaglandin j2 and rs1303) on proliferation, differentiation, apoptosis and invasion. Five cell lines showed higher level of the pparc gene and protein expression than papillary thyroid carcinoma. Pparî³ ligands inhibited cell proliferation by inducing apoptosis instead of differentiation in dose-dependent manner. Pparî³ ligands also down regulated the invasive potential of 5 cell lines. The inhibitory effect of proliferation or invasion was prominent in 3 cell lines, which exhibited higher expression level of the pparc gene or protein. generic viagra online cheap viagra online buy viagra online buy cheap viagra viagra for sale cheap viagra online viagra without a doctor prescription cheap generic viagra buy viagra online cheap generic viagra Our results indicated that pparî³ ligands modify malignant potential of anaplastic carcinoma cell lines altering growth or invasive properties, suggesting that pparî³ could be potentially the novel molecular target for human thyroid anaplastic carcinoma. International journal of oncology january 2004volume 24 number 1 viewing options: abstract purchase article sign up for etoc alerts share this article: copyright © 2012.

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